The ACTH stimulation test evaluates function of which gland by measuring cortisol response?

The ACTH stimulation test evaluates function of which gland by measuring cortisol response?

• A. Liver
• B. Adrenal glands
• C. Thyroid gland
• D. Pancreas

Answer: (B)

Measuring cortisol response to ACTH directly tests the adrenal glands’ ability to produce cortisol. ACTH, released by the pituitary, stimulates the adrenal cortex to release cortisol. By checking cortisol levels before and after ACTH administration, you can see how well the adrenal glands respond. A normal rise means the adrenal glands are functioning properly; a blunted or absent rise points to adrenal insufficiency. The liver, thyroid, and pancreas aren’t the primary glands assessed by this test—the liver metabolizes cortisol, the thyroid is regulated by TSH, and the pancreas handles glucose, not cortisol production in response to ACTH.

Measuring cortisol response to ACTH directly tests the adrenal glands’ ability to produce cortisol. ACTH, released by the pituitary, stimulates the adrenal cortex to release cortisol. By checking cortisol levels before and after ACTH administration, you can see how well the adrenal glands respond. A normal rise means the adrenal glands are functioning properly; a blunted or absent rise points to adrenal insufficiency. The liver, thyroid, and pancreas aren’t the primary glands assessed by this test—the liver metabolizes cortisol, the thyroid is regulated by TSH, and the pancreas handles glucose, not cortisol production in response to ACTH.