Pemphigus is a group of autoimmune disorders that affect which tissues?

Pemphigus is a group of autoimmune disorders that affect which tissues?

• A. Blood and lymph systems
• B. Skin and oral mucosa
• C. Eyes
• D. Hooves and claws

Answer: (B)

Pemphigus is caused by autoantibodies that attack proteins responsible for sticking skin and mucosal cells together. This disrupts cell-to-cell adhesion in the stratified squamous epithelium, leading to blistering within the skin and on mucous membranes. Because these adhesion proteins are located in both the skin and oral mucosa, the tissues most affected are the skin and the oral mucosa. The other listed tissues aren’t the primary targets of pemphigus, so they aren’t the typical sites of involvement.

Pemphigus is caused by autoantibodies that attack proteins responsible for sticking skin and mucosal cells together. This disrupts cell-to-cell adhesion in the stratified squamous epithelium, leading to blistering within the skin and on mucous membranes. Because these adhesion proteins are located in both the skin and oral mucosa, the tissues most affected are the skin and the oral mucosa. The other listed tissues aren’t the primary targets of pemphigus, so they aren’t the typical sites of involvement.